Abstract
Purpose. In the present study, the three-dimensional power Doppler was used as a quantitative method to evaluate its reliability in detecting and assessing of gestational trophoblastic disease (GTD). Methods. 52 GTD patients who received diagnosis and treatment at the first affiliated hospitals of Xi'an Jiaotong University in China between 2011 and 2013 were evaluated using Voluson E8 (GE Medical System). Demographic information, pathological characteristics, clinical history, sonographic images, and related indices (resistance index, vascularization index, and flow and vascularization index) were evaluated. Result. Three-dimension power Doppler indicated that there were significant differences in the resistance index, vascularization index, flow index, and vascularization-flow index between the healthy individuals and each subgroup of patients (P < 0.01). Further, in combining invasive hydatidiform mole and choriocarcinoma groups, there was a significant difference between hydatidiform mole and the combined malignant group (P < 0.01). And the abnormal sonographic and power Doppler findings in GTD were resolved when chemotherapy was done successfully. Conclusion. Combined with the clinical features, sonography and three-dimension power Doppler imaging were helpful in diagnosing GTD as a noninvasive method, distinguishing the invasive nature of disease, detecting the recurrence of the disease, and assessing the effectiveness of the chemotherapy.
Highlights
Gestational trophoblastic disease (GTD) is a rare gynecological disease and contains a series of pregnancy-related disorders, which occurs in the delivery, miscarriage, or termination of pregnancy
The study comprised 52 females with a medium age of 30 years. 28 patients were diagnosed as hydatidiform mole, 20 patients were diagnosed with invasive mole, and 4 patients were diagnosed with choriocarcinoma
It can be concluded that low resistance index (RI) and high vascularization index (VI), flow index (FI), and vascularization-flow index (VFI) were found commonly in malignant GTD
Summary
Gestational trophoblastic disease (GTD) is a rare gynecological disease and contains a series of pregnancy-related disorders, which occurs in the delivery, miscarriage, or termination of pregnancy. It consists of the premalignant tumor of complete and partial hydatidiform mole, which might develop into invasive mole, choriocarcinoma, and the rare placental-site trophoblastic tumor in rare cases [1]. The power Doppler has been extensively used in understanding the uterine vasculature. The 3D power Doppler (3D PD) was used as a quantitative method in order to understand its reliability in detecting and following GTD
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