CHARACTERISTICS OF THE CONTENT AND DIAGNOSTIC VALUE OF β2-MICROGLOBULIN IN THE BLOOD AND URINE OF PATIENTS WITH KIDNEY DAMAGE AND MALABSORPTION SYNDROME

Abstract

An important diagnostic study of many diseases, especially in nephrology, is thedetermination of the level of low molecular weight beta-2-microglobulin protein in thehuman body. The main organ of elimination of beta-2-microglobulin from the body is thekidneys, and the extrarenal route of its elimination has not been proved. Therefore, thisprotein is informative in the diagnosis of kidney damage.The aim of the work – to investigate the content of beta-2-microglobulin in the blood andurine of patients with kidney damage and malabsorption syndrome and to determine itsdiagnostic value in this comorbid pathology.Material and methods. 107 patients with kidney damage and the presence of oxaluriaagainst a background of malabsorption syndrome were examined. All patients were testedfor beta-2-microglobulin of the blood and urine by immunoenzymatic method.Results. In patients with malabsorption syndrome, the presence of chronic kidney diseasestage III and with nephrocalcinosis and urolithiasis, the increase in beta-2-microglobulinof the blood and urine was significantly higher compared to the corresponding data of therest of the patients with kidney damage. Similar changes were observed in patients withinterstitial nephritis.Conclusion. An increase of beta-2-microglobulin content in the blood and urine inpatients with kidney damage and malabsorption syndrome indicates the comorbidityof these pathological conditions. This method can be used for early diagnostics of theprogression of both pathological conditions when they are combined.