Characteristics of ternary clove/water/1-butanol microemulsions based drug delivery system for aspirin

Abstract

This work was intended to characterize aspirin solubilized in microemulsion systems comprising clove oil, 1-butanol and water. Microemulsions demonstrated the unique ability to solubilize aspirin in polar media, thus having good potential in drug delivery. After incorporation of aspirin, four samples were selected in microstructure and be investigated by conductivity measurements, transmission electron microscope (TEM), and spectroscopic studies (1H-NMR, UV-visible spectroscopy, and IR spectra). The percolation behavior with variation of weight fraction of aqueous phase (ϕ) was confirmed by conductivity measurements. In order to study the effect of aspirin, the conductivity results of aspirin-loaded samples were compared with non-loaded ones. The proton transfer and The competitive H-bonding interactions between aspirin with butanol and water were also discussed in details using 1H-NMR, UV-visible spectroscopy, and IR spectra. These measurements confirmed that the hydrogen-bonded ion pair structure dominated in the solutions.