Abstract
Aim:To report the main features of sympathetic ophthalmia in a referral ophthalmology center.Methods:Retrospective clinical study. We reviewed clinical records of patients with diagnosis of sympathetic ophthalmia attending the Uveitis Department from 2007 to 2013. Patients were selected by clinical criteria. Descriptive statistics were used to assess variables.Results:Twenty patients were included for analysis, 13 males and 7 females. Mean follow up was 1 year. The median age of presentation was 50 years. Fifty percent had history of ocular trauma and 50% had history of intraocular surgery, of which 40% underwent phacoemulsification. The time between injury and onset of symptoms ranged from 1 to 456 months. Most common ocular manifestations were mutton fat keratic precipitates and anterior chamber inflammation. All patients received oral prednisone as single or combined therapy. Sixty percent of the sympathizing eyes improved two or more lines of vision and 20% lost two or more lines of vision.Conclusion:This report from a single center adds to the body of literature of sympathetic ophthalmia occurring in a specific population. Our data found a high proportion of patients with sympathetic ophthalmia after phacoemulsification.
Highlights
Despite the first complete clinical description by William Mackenzie of sympathetic ophthalmia performed in 1840, its cause has not been completely understood, an autoimmune reaction of exposed ocular antigens is implicated, causing a bilateral granulomatous uveitis involving an eye exposed to trauma or surgery and the fellow eye [1, 2].It is a rare disease, with an estimated incidence of 0.03/100,000 in a study population over 15 months [3]
This is an observational and retrospective clinical study; we reviewed the clinical data of all patients with a diagnosis of sympathetic ophthalmia attending the Department of Uveitis and Ocular Immunology at Instituto de Oftalmologia “Conde de Valenciana” in Mexico city from 2007 to 2013
We had to exclude 22 patients, 12 because of insufficient data in their files, and 10 because they did not fulfill our clinical criteria for sympathetic ophthalmia; 20 patients were included for analysis
Summary
Despite the first complete clinical description by William Mackenzie of sympathetic ophthalmia performed in 1840, its cause has not been completely understood, an autoimmune reaction of exposed ocular antigens is implicated, causing a bilateral granulomatous uveitis involving an eye exposed to trauma or surgery (inciting eye) and the fellow eye (sympathizing eye) [1, 2]. It is a rare disease, with an estimated incidence of 0.03/100,000 in a study population over 15 months [3]. The goal of this study is to report the characteristics of patients with sympathetic ophthalmia in a referral center in Mexico in a period of seven years
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