Abstract
Sustained tremor (nicotine pilocarpine tremor) was produced by the administration of nicotine to pilocarpine pretreated mice and rats. and its characteristics were studied. Nicotine pilocarpine tremor was composed of tremor of the head and limbs and occasional sharp head movements up and backwards. Pilocarpine caused hyperthermia in most of the rats kept in a high ambient temperature (30 32 C) and also induced hypothermia under normal conditions (22 ± 2 C). Nicotine produced the sustained tremor only in rats which showed a rise in body temperature by pilocarpine pretreatment. In mice pretreated with pilocarpine, nicotine produced the sustained tremor under normal conditions as well. The time course of nicotine elimination from brain was dissociated from that of the intensity and duration of the sustained tremor. Atropine, nicotinolytic drugs, promethazine, phenobarbital and propranolol blocked the induction of nicotine-pilocarpine tremor. l-Dihydroxyphenylalanine, α-methyldopa, reserpine and tolazoline were not effective. It is suggested that nicotine-piloearpine tremor does not solely result from the inhibition of hepatic drug metabolism by pilocarpine, and that the central cholinergic system might be involved in the induction of nicotine pilocarpine tremor.
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