Characteristics of Small Bowel Polyps Detected in Cowden Syndrome by Capsule Endoscopy.

Keita Saito,Naoko Mizumoto,Yu Sasaki,Nana Kanno,Kazuhiro Sakuta,Rika Shibuya,Shoichi Nishise,Takeshi Sato,Kazuya Yoshizawa,Eiki Nomura,Makoto Yagi,Yasuhiko Abe,Yoshiyuki Ueno,Daisuke Iwano

doi:10.1155/2015/475705

Keita Saito, Naoko Mizumoto + Show 12 more

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https://doi.org/10.1155/2015/475705

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Abstract

Cowden syndrome is an uncommon, autosomal dominant disease characterized by multiple hamartomas and hyperplastic lesions in the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract. About 30% of Cowden syndrome cases are reportedly complicated by malignant diseases. Hamartomatous polyps occur throughout the gastrointestinal tract, the most common sites being the stomach, colon, esophagus, and duodenum. Small bowel polyps can occur in Cowden syndrome; however, they are difficult to detect by conventional examination, including double-contrast X-ray study. Here, we report three cases of Cowden syndrome with small bowel polyps, which were detected by capsule endoscopy. The small bowel polyps of Cowden syndrome frequently occur at the oral end of the small bowel, especially in the duodenum and jejunum, and their color is similar to that of the surrounding mucosa; additionally, the polyps are relatively small (2–5 mm). Capsule endoscopy is useful for detecting small bowel polyps in Cowden syndrome.

Highlights

Cowden syndrome is an uncommon, autosomal dominant disease characterized by multiple hamartomas and hyperplastic lesions of the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract [1, 2]
The small bowel polyps can occur in Cowden syndrome; the characteristics of these polyps are unclear, and they are difficult to detect by conventional examination, including double-contrast X-ray study [6]
We report three cases of Cowden syndrome with small bowel polyps, which were detected by capsule endoscopy (CE), and describe the characteristic findings of the small bowel polyps in this syndrome

Summary

Introduction

Cowden syndrome is an uncommon, autosomal dominant disease characterized by multiple hamartomas and hyperplastic lesions of the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract [1, 2]. Its incidence is estimated to be one in 200,000–250,000 [3]. About 30% of Cowden syndrome cases are reportedly complicated by malignant tumors [4]. The incidence of gastrointestinal polyps is 65.6% in the esophagus, 75% in the stomach, 36.5% in the duodenum, and 65.6% in the colon [5]. The small bowel polyps can occur in Cowden syndrome; the characteristics of these polyps are unclear, and they are difficult to detect by conventional examination, including double-contrast X-ray study [6]. We report three cases of Cowden syndrome with small bowel polyps, which were detected by capsule endoscopy (CE), and describe the characteristic findings of the small bowel polyps in this syndrome

Case Reports

Findings

Discussion