Characteristics of serum lipid levels in 899 centenarians of Hainan

Abstract

Objective To investigate the characteristics of serum lipid levels in centenarians in Hainan province. Methods A total of 899 centenarians were enrolled.Fasting venous blood samples were collected, and serum levels of total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), apolipoprotein A-1(Apo A1), apolipoprotein B(Apo B)and lipoprotein(a)[Lp(a)]were determined.Characteristics of serum lipid levels in centenarians with different age and gender were analyzed. Results The ratio of male to female in this study was 1∶4, 101 years of age comprised the largest proportion(20.4%, 183 cases), and the highest age was 109 years old for men and 116 years old for women.People aged 102 years had the highest levels of TC, TG, LDL-C and Apo B, and also had the lowest levels of HDL-C and Apo A1.Serum levels of TC and LDL-C reached the peak at the age of 102 years and showed downward trends year by year.Serum levels of TC, TG, LDL-C, Apo A1 and Apo B were lower in males than in females(P 0.05). The detection rates for abnormal serum lipid levels were higher in females than in males(P<0.01). Serum Lp(a)level was higher in females than in males. Conclusions Serum lipid levels show a peak expression at a certain age in centenarians of Hainan, and the types and ratio of abnormal blood lipids are higher in female centenarians than in male centenarians. Key words: Centenarians; Blood lipid