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Abstract
Selenium polysaccharide is an organic selenium compound, which has attracted much attention because of its unique biological properties. In the current study, a new selenium polysaccharide (Se-SCP) was synthesised, and its structure and effects on non-enzymatic glycosylation in vivo were studied. The molecular weight of Se-SCP was 9.02 g/mol, and its molecule was mainly composed of Man, Gal, GluA, Ara, Glu, Fuc, Rha, GalA, and Xyl. Selenium was present both as C–O–Se and Se=O. Compared with non-selenised sweet corncob polysaccharide (SCP) treatment, the blood glucose level in mice decreased considerably after Se-SCP treatment. Additionally, it improved oral glucose tolerance (OGTT) and significantly reduced the production of advanced glycation end-products (AGEs) (P < 0.05), compared with the model group. In addition, Se-SCP exhibited a positive effect on the morphology of the pancreas and liver. The current study elucidated the physiological and pharmacological effects of selenium polysaccharides and provided a basis for future studies on selenium polysaccharides.
Highlights
Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with islet β-cell dysfunction and has organ insulin resistance as its crucial aspect. [1]
The current study evaluated the structural characteristics and molecular morphology of selenium polysaccharide (SeSCP) from sweet corncob using analytical techniques
Characterization of Se‐sweet corncob polysaccharide (SCP) Molecular weight analysis Compared with the natural polysaccharide, the molecular weight (MW) of the SCP after selenisation was slightly lower, and the molecular distribution was narrow
Summary
Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with islet β-cell dysfunction and has organ insulin resistance as its crucial aspect. [1]. Characterization of Se‐SCP Molecular weight analysis Compared with the natural polysaccharide, the MW of the SCP after selenisation was slightly lower, and the molecular distribution was narrow. Our results indicated that selenium exists as selenite in Se-SCP because selenite forms after removing a water molecule from –OH in the polysaccharide molecule and –OH from the H2SeO3 molecule.
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