Abstract

This cohort study compares the characteristics of infections from SARS-CoV-2 variants spreading during August to October 2020 vs the variants spreading during December 2020 to February 2021 among children in Israel.

Highlights

  • Since December 2020, the SARS-CoV-2 B.1.1.7 variant has been spreading in Israel, and by January or February 2021 it quickly became the predominant circulating strain, isolated in more than 80% of cases.[1]

  • Data were analyzed for 21 615 children aged 0 to 9 years (50.9% male children) who had positive SARS-CoV-2 polymerase chain reaction tests between August 1 to October 2, 2020, and for 50 811 children aged 0 to 9 years (51.5% male children) who tested positive between December 3, 2020, and February 3, 2021

  • The percentage of hospitalized children with unfavorable outcomes out of total number of hospitalizations was not different between the 2 periods. These results demonstrate that SARS-CoV-2 spread more effectively and more rapidly among young children during the time of B.1.1.7 variant circulation in Israel

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Summary

Introduction

Since December 2020, the SARS-CoV-2 B.1.1.7 variant has been spreading in Israel, and by January or February 2021 it quickly became the predominant circulating strain, isolated in more than 80% of cases.[1]. The aim of this study was to compare the characteristics of SARS-CoV-2 spread in children, aged 0 to 9 years, in 2 periods when different SARS-CoV-2 variants were circulating: August to October 2020, when former SARS-CoV-2 variants (mostly GH and GR clades)[2] circulated, and December 2020 to February 2021 since the introduction of the B.1.1.7 variant in Israel

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