Characteristics of phosphate transport across the basolateral membrane of the proximal tubule: an in vivo study.

Abstract

The final event in renal epithelial phosphate absorption is the movement of phosphate from the cytosol across the basolateral membrane into the peritubule capillary. The transmembrane potential difference is about −65 mV and the chemical concentration gradient is in the order of 1–5 mM inside-to-3mM outside. Accordingly, the transfer of phosphate may be passive down its electrical gradient. This is thought to be facilitated by a phosphate carrier within the basolateral membrane 1,2,3,4.