Abstract

ObjectiveAir pollution has been widely recognized to pose a threat to health. Urban outdoor air pollution was listed as the 14th biggest risk factor for global deaths in 2004 in the Global Health Risks report published by the World Health Organization in 2009. Many past studies have indicated that exposure to environmental contaminants promotes changes in the internal mechanisms of diseases, including the infection of various systems in the body, hormonal changes, and vascular proliferation. These changes may be related to the severity of endometrial hyperplasia. Therefore, this study used the air quality monitoring data of the Environmental Protection Administration (EPA) to examine the effects of air pollutant concentration on patients with endometrial hyperplasia. Materials and methodsThis population-based nationwide study used data for 2002–2013 from the National Health Insurance Research Database of Taiwan. Patients who developed endometrial hyperplasia before 2002 were excluded. In total, 14,883 patients with endometrial hyperplasia were tracked. The exposure levels and air quality index (AQI) values in this study were based on the taiwan air quality monitoring network data collected by the EPA from 2000 to 2013. The data were further divided into the good air quality group (AQI ≤ 50) and poor air quality group (AQI > 50). The study used linear regression model to estimate the correlation linking air pollutant concentration with endometrial hyperplasia. ResultsThe results indicated that, in comparison to endometrial hyperplasia patients who were exposed to air with good quality, those exposed to air with poor quality had a higher average age (p < 0.001) and higher proportion of living in southern Taiwan (p < 0.001), as well as higher rates of diabetes (p < 0.001), hyperlipidemia (p < 0.001), hypertension, cerebrovascular diseases (p = 0.024), cerebral vascular accidents (p = 0.024), and chronic kidney disease (p < 0.001). ConclusionThe patients with endometrial hyperplasia in poor AQI area had severe comorbidity. Thus, attention must be paid to the improvement of air quality and the implementation of preventive measures against contaminants.

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