Abstract
ObjectiveTo assess incidence and burden of neonatal herpes simplex virus (HSV) infections and to explore possible transmission routes.MethodsA 2-year prospective nationwide surveillance study performed in 2017 and 2018. All German...
Highlights
Neonatal herpes simplex virus (HSV) infections are rare
For comparison with the data of our cohort study, we present the incidence of neonatal HSV infections per 100 000 live born infants with the health data reported to the German Federal Statistical Office by the statutory health insurances companies
The 2-y ear incidence of neonatal HSV infections was 2.35 per 100 000 live births
Summary
Neonatal herpes simplex virus (HSV) infections are rare. In the USA and Canada, the incidence has been estimated to be around 6–10 cases per 100 000 live births.[1 2] It is commonly assumed that about 85% of infants become infected in the intrapartum period, 10% postnatally and 5% in utero.[3] in many cases, the exact mode of transmission cannot be determined.[2] Neonatal HSV infections are usually apparent before 14 days of life, but later manifestations have been described. The two specific types of HSV, HSV-1 and HSV-2, both cause neonatal infections.[4] Mother- to-child transmission is significantly increased in primary versus recurrent maternal infections, during vaginal delivery versus caesarean section and in infection with HSV-1 versus HSV-2.5 Maternal
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