Abstract
miRNAs is a class of nano-sized non-coding RNAs that regulate the expression of genes, and associated with many physiological and pathological processes, especially cancer. The expression of many genes is regulated by the binding of their mRNA with miRNA, so it is required to identify which candidate genes of oncogenesis and to what extent can interact with miRNA. The purpose of this work was to establish the characteristics of the interaction of known 3707 miRNA with mRNA of 38 candidate esophageal adenocarcinoma genes. It has been identified, that 84 miRNAs have binding sites in 31 mRNAs of genes at 5'UTR, CDS, and 3'UTR and the average free binding energy (ΔG) of miRNAs with mRNAs was -121 kJ/mole, -118 kJ/mole and -113 kJ/mole, respectively. 19 associations of miRNAs and mRNA of genes with a free energy of interaction more than -120 kJ/mole are recommended for the diagnosis of esophageal adenocarcinoma. The mRNAs of most genes containing two or more miRNA binding sites with overlapping of their nucleotide sequences form clusters. Based on the obtained results, associations of miRNA and mRNA of candidate genes are recommended to develop methods for early diagnosis of esophageal adenocarcinoma. Key words: mRNA, miRNA, genes, oncological diseases, esophageal adenocarcinoma
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
