Abstract
Methionine can be oxidized to methionine sulfoxide, causing redox imbalance in vivo and inducing many diseases. Methionine sulfoxide reductases (Msrs) can reduce methionine sulfoxide to methionine, thus renovate protein structure and function, and prevent oxidative stress-relevant diseases. This review mainly includes the classification and evolution of Msrs, the protein structural feature and catalytic mechanism, and protein expression via genetic engineering. It summarizes recent development in Msrs and aging or Parkinsons disease or Alzheimers disease, as well as our own results. The prospect of Msrs research is also discussed in this paper.
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