Abstract
Ganglioside mimicry by C.jejuni lipo-oligosaccharides (LOS) could induce the production of autoantibodies against gangliosides and the development of Guillain-Barré syndrome (GBS). The LOS biosynthesis region exhibits significant variation with different strains. Using PCR amplifications of genes from published LOS loci and sequencing the LOS biosynthesis loci, the eight GBS-associated C. jejuni strains from HeBei could be classified into four classes. The expression of sialylated LOS structures (class A) or non-sialylated LOS structures(class F, H and P) in the C. jejuni LOS is considered to be two different factors for the induction of GBS.
Highlights
Campylobacter jejuni (C. jejuni) is the leading cause of acute bacterial gastroenteritis worldwide
The association between C. jejuni and the development of Guillain-Barré syndrome (GBS) is thought to result from the molecular mimicry between outer core structures of bacterial lipo-oligosaccharides (LOS) and gangliosides in peripheral nerves [1,2,4,5,6]
According to the general organization of the LOS biosynthesis genes, the eight C. jejuni strains in this study could be classified into four classes “A,” “F,” “H,” and “P”
Summary
Campylobacter jejuni (C. jejuni) is the leading cause of acute bacterial gastroenteritis worldwide. It has been associated with the development of Guillain-Barré syndrome (GBS), a post-infectious polyneuropathy [1,2,3,4]. A recent study identified 11 new classes of LOS loci that were distinctly different from the previous eight classes [11]. They demonstrated the insertions and deletions of genes were related among different LOS classes. The characteristics of loci involved in the biosynthesis of the LOS outer core from eight C. jejuni strains isolated from GBS patients in Hebei, China were studied
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