CHARACTERISTICS OF LIPID STORAGE DISORDERS IN CHILDREN WITH HEPATOBILIARY PATHOLOGY

L V Korkotashvili,G V Dmitrieva,E I Shabunina,L N Varnacheva,А E Lavrova,D V Bystranova,S А Kolesov

doi:10.15690/vsp.v13i2.980

Abstract

It was recorded that hepatobiliary system disorders, which are associated with lipid storage disorders, in children became more frequent over the last years. The above-stated pathology in childhood is understudied and little-known among practitioners. Background : To study changing rules of lipid metabolism for diagnostics development and prevention of hepatobiliary system disorders associated with dyslipidemia. Patients and methods : 53 children aged 2 to 17 years divided in 3 groups were examined: the 1st — 16 persons with familial hypercholesterolemia and disorders in hepatobiliary system; the 2nd — 11 children with liver glycogenoses; the 3rd — 26 patients with chronic cholecystitis. Results: Changing rules of lipid metabolism showed: in the 1st group — persistent hypercholesterolemia and rise in level of low-density lipoproteins; in the 2nd — combination of hypercholesterolemia with hypertriglyceridemia in roughly the instances, free fatty acids over limits; in the 3rd — decrease in the level of phospholipids in blood serum and (due to BMI > 20 kg/m2) hyperleptinemia. Conclusion: Disorders in the level of phospholipids and free fatty acids in blood serum may be used additional criteria for diagnostics of chronic cholecystitis and liver disease in children, as well reason for prescription of essential phospholipids in therapeutic sequence.

Highlights

В последние годы отмечено повышение частоты развития заболеваний гепатобилиарной системы у детей, которые ассоцируются с нарушениями липидного обмена
It was recorded that hepatobiliary system disorders, which are associated with lipid storage disorders, in children became more frequent over the last years
To study changing rules of lipid metabolism for diagnostics development and prevention of hepatobiliary system disorders associated with dyslipidemia

Summary

Introduction

В последние годы отмечено повышение частоты развития заболеваний гепатобилиарной системы у детей, которые ассоцируются с нарушениями липидного обмена. Пациенты и методы: обследовано 53 ребенка в возрасте от 2 до 17 лет в 3 группах: 1-я — 16 человек с семейной гиперхолестеринемией и наличием отклонений со стороны гепатобилиарной системы; 2-я — 11 детей с гликогенозами печени; 3-я — 26 пациентов с хроническим холециститом.

Results

Conclusion