Abstract
Sasakawa, Nobuyuki, Toshio Nakaki and Ryuichi Kato: Characteristics of Inositol polyphosphate Metabolism in cultured adrenal chromaffin cells. Prog. NeuroPsychopharmacol. & Biol. Psychiat. 1993, : 17(5): 825–834. 1. 1. Nicotine, high K + and maitotoxin caused the inositol polyphosphate accumulation concomitant with 45Ca 2+ uptake. 2. 2. Angiotensin II (Ang II) and ATP induced the inositol polyphosphate accumulation without 45Ca 2+ uptake. 3. 3. Nifedipine-treatment and Ca 2+-deprivation inhibited the high K +-induced inositol polyphosphate accumulation but failed to inhibit the Ang II-induced inositol polyphosphate accumulation. 4. 4. 12-O-tetradecanoylphorbol-13-acetate inhibited the Ang II-induced inositol polyphosphate accumulation but failed to inhibit the high K +-induced one 5. 5. These results suggest that the formation of inositol polyphosphates may be regulated by two mechanisms i.e. Ca 2+ uptake-dependent mechanisms represented by high K +, and Ca 2+ uptake-independent mechanisms represented by Ang II.
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