Abstract
Previous studies have suggested that mother-to-childtransmission of HIV-1 is often characterized by acquisi-tion of a homogeneous viral quasispecies in the infant [1-3], suggestive of a genetic bottleneck. In this study, wehave analyzed the molecular characteristics of transmittedHIV-1 viruses in a homogeneous population infected byCRF01_AE variants in Thailand.
Highlights
Previous studies have suggested that mother-to-child transmission of HIV-1 is often characterized by acquisition of a homogeneous viral quasispecies in the infant [13], suggestive of a genetic bottleneck
We have analyzed the molecular characteristics of transmitted HIV-1 viruses in a homogeneous population infected by CRF01_AE variants in Thailand
Our data indicate that 4 potential N-linked glycosylation sites (PNGS) positions (N241, N301, N354, and N384) that appeared conserved in all infant variants but were irregularly present in the mothers might be associated to a selective advantage
Summary
Previous studies have suggested that mother-to-child transmission of HIV-1 is often characterized by acquisition of a homogeneous viral quasispecies in the infant [13], suggestive of a genetic bottleneck. We have analyzed the molecular characteristics of transmitted HIV-1 viruses in a homogeneous population infected by CRF01_AE variants in Thailand
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