Abstract
Type 2 diabetes mellitus (T2DM) is an important public health issue worldwide. T2DM correlates with cardiovascular disease. Arterial stiffness is also a key factor that can be thought of as a surrogate marker. Nevertheless, it was unclear which harmonic indexes of blood pressure waveforms (BPWs) from subjects' radial artery pulses would be affected by T2DM. Therefore, the objective of this study was to investigate whether and how harmonic indexes can be used to discriminate hemodynamic differences between patients with T2DM and non-T2DM. This helps us to build objective results no matter who conducts the examination instead of pulse diagnosis in traditional way. We enrolled T2DM and non-T2DM patients as experimental and control groups, respectively, from the Department of Family Medicine in the National Taiwan University Hospital and the Department of Internal Medicine in Taipei's Veterans General Hospital from December 2017 to January 2019. ANSWatch® Model TS-0411 was used to capture the BPWs. Amplitude proportions (Cn values) were calculated from harmonics 1–10 of the BPW using fast Fourier transform. Thirty-two T2DM and 15 non-T2DM patients were enrolled. T2DM patients had significant differences in C1 (p = 0.031) and C5 (p = 0.041). The study suggests that analyzing the harmonic characteristics of non-invasively measured BPW of radial artery may be a potential and easy-to-perform approach to discriminate T2DM-induced hemodynamic changes.
Highlights
Diabetes mellitus (DM) is one of the most important public health issues worldwide
Body mass index was higher in type 2 diabetes mellitus (T2DM) patients (p = 0.032)
Any increase in body mass index above normal weight levels is associated with an increased risk of being diagnosed with DMrelated complications (Gray et al, 2015); this is aligned with our findings in this study
Summary
Diabetes mellitus (DM) is one of the most important public health issues worldwide. The vast majority of diabetes patients have type 2 diabetes mellitus (T2DM). In 2014, it was estimated that 422 million adults above 18 years of age suffered from DM worldwide (WHO, 2016). The global prevalence of DM in 1980 was 4.7%, but it had risen to 8.5% by 2014. Being overweight or obese is strongly linked to diabetes occurrence (WHO, 2016). The trends in the complications of diabetes are cardiovascular disease, chronic kidney disease, loss of vision and lower extremity amputations
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