Abstract
This study is aimed to know the characteristics and the effectivity of gel emulsion of snakehead (Channa micropeltes) extract in accelerating wound healing process. It used experimental method with Complete Randomized Design. Four treatments with 3 replications were employed, i.e. 1%, 2%, and 4% gel emulsion of snakehead Channa micropeltes extract and a control treatment. Results showed that C. micropeltes extract formulated in gel emulsion had white colour, typical aroma of gel emulsion, soft texture with mean dispersion ability of 3 cm, and pH 6. In vivo test on male mices that gel emulsion of C. micropeltes extract was highly effective (P≤0.05) to accelerate wound healing, in which the treatment of 1% gel emulsion gave the highest effect with 98.5% wound healing at day-14, followed with that of control treatment, 95% healing, then 2%, 90% healing and 4%, 90% healing, respectively. Snakehead (Channa micrpeltes) extract formulated in gel emulsion can speed up the wound healing process.
Highlights
Wounds are damages of body tissues often followed with loss of tissue substance that disturbs normal cellular process of the body, skin (Sinambela et al 2013; Daisa et al 2017)
Wound healing is a natural process of the body in regeneration of damaged skin tissue by supplying tissue perfusion, sufficient oxygen, and appropriate nutrition
Gel emulsion production is an alternative solution in wound healing drug development
Summary
Wounds are damages of body tissues often followed with loss of tissue substance that disturbs normal cellular process of the body, skin (Sinambela et al 2013; Daisa et al 2017). Wound healing is a natural process of the body in regeneration of damaged skin tissue by supplying tissue perfusion, sufficient oxygen, and appropriate nutrition. One of the principles in wound healing is to provide enough nutrients since nutrient intake is highly needed to increase the wound strength, to decrease dehydration, and to reduce the vulnerability to infection. Nutrient intake, such as carbohydrate, protein, fat, and micronutrients, is very important in increasing the body defense mechanisms to help wound healing process (Widjianingsih & Wirjatmadi, 2013). Gel emulsion production is an alternative solution in wound healing drug development
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