Abstract
Chronic obstructive pulmonary disease (COPD) often accompanies type 2 diabetes mellitus (T2DM). However, background factors affecting these diseases in the elderly remain unclear. Eligible patients with T2DM were divided into two age groups—non-elderly (<65 years) and elderly (≥65 years); COPD, ratio of forced expiratory volume in one second to forced expiratory volume (FEV1/FVC ratio), and percent predicted forced expiratory volume in one second (FEV1% predicted) were examined, and factors related to reduced respiratory function according to age group were evaluated. In total, 371 patients with T2DM were analysed. COPD was found in 9 patients (5.3%) in the non-elderly group and 45 (22.5%) in the elderly group. In the elderly, male sex, low body mass index (BMI), insulin therapy, and high C-peptide immunoreactivity levels were factors related to COPD. In the non-elderly, age, female sex, high BMI were factors related to decreased FEV1% predicted. Female sex was factor related to decreased FEV1% predicted in both age groups. Low BMI was a factor related to reduced respiratory function in elderly patients and high BMI was a factor related to reduced respiratory function in non-elderly patients. Thus, BMI needs to be managed according to the age and general condition of T2DM patients.
Highlights
Chronic obstructive pulmonary disease (COPD) often accompanies type 2 diabetes mellitus (T2DM)
We found that low body mass index (BMI), insulin therapy, and increased CPR levels were factors related to COPD and reduced FEV1/forced vital capacity (FVC) ratio in the elderly group
High BMI was a factor related to reduced FEV1% predicted in the non-elderly group
Summary
Chronic obstructive pulmonary disease (COPD) often accompanies type 2 diabetes mellitus (T2DM). Male sex, low body mass index (BMI), insulin therapy, and high C-peptide immunoreactivity levels were factors related to COPD. In the non-elderly, age, female sex, high BMI were factors related to decreased FEV1% predicted. Ranked according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD): stage 1 (16.1%), stage 2 (23.5%), stage 3 (9.3%), and stage 4 (5.9%)[18] These data indicate that there are fewer obese patients with severe rather than mild or moderate COPD. The relationship between body fat and respiratory function in elderly patients with T2DM remains unclear. We examined factors influencing respiratory function in patients of two age groups with T2DM
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