Characteristics of esophageal motility of different types of achalasia patients by high resolutionmanometry

Abstract

Objective To investigate the dynamic changes in achalasia patients by using high resolution manometry （HRM）. Methods Twenty-four achalasia patients were enrolled for HRM examination and typing. The esophageal pressure of patients with different subtypes was analyzed. Chi-square test was used for count data analysis. Two independent samples t-test was used for measurement data. Results Among twenty-four achalasia patients, five patients were type Ⅰ and male- dominated, 18 patients were type Ⅲ and female was more than male, and only one male patient was type Ⅱ. The frequency of weight loss in type Ⅰ was higher than that of type Ⅱ （Z =6.97, P=0. 008）. The frequency of chest pain and food reflux in type I was higher than that of type Ⅱ （both P〉0.05）. The average distance from the nares to the upper edge of the lower esophageal sphincter （LES） with the electrode successfully inserted into the stomach was （44.9±3.3） cm and to the lower edge of the LES was （48.0±3.2） cm. The average LES length was （3. 1±0.7 ） cm, average intraabdominal LES length was （2. 1 ±0.5） cm. The average LES resting pressure was （34. 6±13.8） mm Hg （1 mm Hg= 0. 133 kPa） and the integrated relaxation pressure （IRP） was （31. 1± 12.0） mm Hg. Conclusion Esophageal manometry is the golden standard for achalasia diagnosis, and HRM may be a simple, direct-viewing and accurate method for accessing esophageal motor function. Key words: Esophageal achalasia~ Manometry~ Kinetics