Abstract
Cerebral small vessel disease is a major cause of stroke and vascular dementia; however, the pathogenesis is largely unclear. In this study, we investigated the characteristics of the impairment of dynamic cerebral autoregulation (dCA) in lacunar infarction patients. Seventy-one lacunar infarction patients were enrolled in the study, including 46 unilateral middle cerebral artery (MCA) territory stroke patients and 25 unilateral posterior cerebral artery (PCA) territory stroke patients. Each group of patients was randomly divided into two subgroups. Group 1 underwent dCA assessments in the bilateral MCAs, and Group 2 underwent dCA assessments in the bilateral PCAs. All patients were followed up for 6 months. Transfer function analysis was applied to derive the autoregulatory parameters of gain and phase difference. In the unilateral MCA territory stroke patients, impairments of dCA were observed in both the MCAs and PCAs, and the same results were observed in the unilateral PCA territory stroke patients. These impairments remained unchanged during the 6-month follow-up. In lacunar infarction, which is most prevalent type of cerebral small vessel disease, though patients with unilateral MCA territory/PCA territory stroke, the impairments of dCA were global and sustained. This finding suggests that the physiological changes associated with lacunar infarction were diffuse.
Highlights
Male Age Mean blood pressure Heart rate Endtidal CO2 NIHSS score Hyperlipidemia Smoking Excessive drinking
We found that in unilateral middle cerebral artery territory stroke patients, dCA impairments were observed in both of the middle cerebral arteries and posterior cerebral arteries, and the same results were observed in the unilateral posterior cerebral artery territory stroke patients
These impairments remained unchanged at the 6-month follow-up. These results indicated that the dCA impairments in lacunar infarction were global and sustained
Summary
Male Age (years) Mean blood pressure (mmHg) Heart rate Endtidal CO2 (mm Hg) NIHSS score Hyperlipidemia Smoking Excessive drinking. 46 unilateral middle cerebral artery territory stroke patients
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