Abstract
Rous sarcoma virus-Rous associated virus (RSV-RAV 1) mixtures were treated to remove lipoprotein envelopes, and the resulting virion cores were analyzed. Cores labeled with uridine- 3H had a density (1.27 g/ml) different from intact virus (1.16 g/ml) and could be separated by isopycnic banding in potassium tartrate, cesium sulfate, or sucrose gradients. The viral RNA within the cores was susceptible to ribonuclease, and the general instability of cores could partially be explained on this basis. Cores obtained from murine leukemia virus had properties similar to those of RSV-RAV 1. Density-purified cores exhibited complement-fixing activity when mixed with group-specific antiserum, but most of the group specific antigen was solubilized during processing of virions. Electron microscopic observations on the cores are presented.
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