Characteristics of cerebrospinal fluid biomarkers/imaging findings in ptaients with amyloid PET‐negative dementia

Abstract

AbstractBackgroundIn daily clinical practice, we often encounter cases with atypical clinical symptoms and imaging findings, even amoung those diagnosed with Alzheimer’s disease.MethodForty‐nine cases of undiagnosed patients with atypical clinical symptoms or imaging findings underwent both amyloid PET and cerebrospinal fluid(CSF) examinations.They were divided into amyloid‐positive group(n = 25) and amyloid‐negative group(n = 24).The cerebrospinal fluid findings,neuropsychological examination findings,MRI findings,and SPECT findings were compared between the two groups.ResultCSF findings showed significant differences in amyloid‐β42,amyloid‐β42/40, and P‐tau between the two groups.There was no significant difference in MRI findings.SPECT findings showed a significant difference in decreased blood flow in the right parietal lobe and bilateral precuneus.ConclusionIn dementia patients with atypical clinical symptoms and imaging findings, CSF findings and decreased blood flow in the right parietal lobe and bilateral precuneus are suggested to be useful indicators to distinguish whether amyloid is involved in the back ground pathology.