CHARACTERISTICS OF BONE TISSUE REGENERATION IN THE VERTEBRAL BODIES IN THE EXPERIMENT WITH OSTEOGRAFT

Abstract

Aim. To assess osteogenic potentialities of a three-di- components, enzymes and vessels with endothelial lining. mensional osteograft in a mini pig model with artificial Structural composition of the osteograft is an analogue of vertebral body defect. The osteograft consists of osteo- embryonic bone tissue, which was the basis for examining the regenerative potentialities of the osteograft in the ex-periment. Methods. The osteograft was implanted in the defect of the lumbar vertebral body of minipig (6 months old). The animals were withdrawn from the experiment in the period from 14 days to 6 months. In the control series, autobone was implanted in a similar defect. The preparations were examined by morphological methods, and bone tissue density was assessed by MSCT. Results. Regeneration and integration of the bone tissue of the vertebral body with the defect replaced by the osteograft was by primary angiogenic osteogene sis within one month due to the structural components of the osteograft. When the defect is replaced by autograft, the regeneration and integration of the bone tissue of the vertebral body occur within six months due to the structural components of the recipient. Conclusion. Formation of the common blood flow of the transplant and recipient vessels is both a factor of integration of the transplant into the homeostatic system of the recipient, and a pathogenic mechanism for optimizing the regeneration of bone tissue defect on the basis of the graft.