Characteristics of Anxiety Manifestations and Hormonal Profile of Women with Threatened Interruption of Pregnancy, Living in Lugansk Region

Abstract

The threatened interruption of pregnancy (TIP) is the most common pregnancy complication that occurs in 15-20% of cases of ongoing pregnancy. The aim of the study was to identify the prevalence and severity of anxiety, the hormonal profile of in pregnant women with threatened interruption of pregnancy in the I and II trimesters, living in the Lugansk region in the area of armed conflict in Eastern Ukraine, to improve treatment and prophylactic measures and prevent obstetric and perinatal complications in such women. Material and methods. The study included 67 pregnant women who were hospitalized regarding TIP to the hospitals, located in the Lugansk region (group I). The control group consisted of 30 pregnant women with non-complicated obstetric anamnesis and physiological course of pregnancy with similar gestational period of pregnancy and place of residence (group II). Spielberger State-Trait Anxiety Inventory was used to assess the level of anxiety, quantitative assessment of concentration of estradiol, progesterone, prolactin, cortisol in blood plasma was determined. Results and discussion. Prevalence of anxiety disorders among pregnant women with TIP living in the armed conflict area was in 2.4 times more often than healthy pregnant women and made up 68,60%. They have significantly higher levels of state and trait anxiety; a positive correlation between the level of state anxiety and concentrations of cortisol, prolactin were found. Conclusions. Antenatal study of levels of anxiety, hormonal homeostasis in pregnant women with TIP living in the armed conflict area allowed to individualize the approach to the management of pregnancy and if needed to timely develop rehabilitating activities, that will contribute to a successful outcome of the pregnancy and affect the health of the mother and her offspring.