Characteristics of adult osteosarcoma patients: Results from an ongoing postmarketing drug safety surveillance study.

Abstract

1608 Background: Adult osteosarcoma is very rare (approximately 2 to 3 per million cases per year in adults aged 40 years and older), and few population-based or large case series studies are reported in the literature. To monitor for a potential signal of a possible association between teriparatide treatment and adult osteosarcoma, a 15-year surveillance study was initiated in 2002. Objectives:To characterize the demographic profile plus environmental and treatment exposures in adult osteosarcoma patients from an ongoing surveillance study. Methods: Incident cases of adult osteosarcoma diagnosed on or after January 1, 2003, are identified through population-based state cancer registries and comprehensive cancer center registries in the United States. Currently, 15 U.S. registries are participating (11 states, 1 SEER, and 3 comprehensive cancer centers). Once cases are identified and consent is obtained, information about demographics, prior treatment with osteoporosis medications, and exposure to possible osteosarcoma risk factors is ascertained by telephone interview. Results: As of September 2009, 979 cases of osteosarcoma diagnosed between January 1, 2003, and December 31, 2007, were identified and 365 interviews were completed (231 patients, 134 proxies). Characteristics were similar for interviewed and non-interviewed cases. Among all cases identified, mean age was 63 years, 49% were female, and 80% were white. Osteosarcoma NOS (67%) and chondroblastic osteosarcoma (12%) were the most common morphologic types; leg bones (29%) were the most common anatomical tumor site, followed by the pelvis/sacrum (17%). Among those interviewed, reported prevalence of possible risk factors was 27% for prior history of cancer, 20% for history of radiation therapy, 20% for prior trauma or infection at site of cancer, and 6% for history of Paget's disease. Conclusions: Data from this ongoing surveillance study are adding to the collective knowledge about adult patients with osteosarcoma. Results through the first 7 years of the study expand on information from the literature and describe the distribution of possible risk factors among adult osteosarcoma patients from a population-based case series. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Lilly Lilly Lilly