Abstract
Salivary gland neoplasms are uncommon, and their epidemiology in Japan has not been well described. We conducted a retrospective review of salivary gland tumors registered in the Hiroshima Tumor Tissue Registry over a period of 39 years. The subjects were 5015 cases ranging in age from 6 to 97 (mean, 54.3) years old. The incidence of both benign tumors and malignant tumors increased with age until 60–69 years and then declined. Among the 5015 salivary gland neoplasms, 3998 (80%) were benign and 1017 (20%) were malignant. Pleomorphic adenoma (PA) was the most frequent benign tumor (68%), followed by Warthin tumor (26%). Adenoid cystic carcinoma (ACC) (27%) and mucoepidermoid carcinoma (MEC) (26%) were the two most frequent malignant tumors. Characteristically, there was a very low incidence of polymorphous adenocarcinoma in Japan. The average annual age-adjusted incidence rate per 100,000 population was 3.3 for benign tumors and 0.8 for malignant tumors. This is the large-scale multi-institutional analysis to describe the characteristics of salivary gland neoplasms, based on the pathological tissue registry data. We hope that the present data can contribute to early diagnosis and effective treatment of salivary gland tumors and to cancer prevention.
Highlights
Salivary gland tumors are relatively rare neoplasms accounting for 3–10% of all head and neck tumors, with an estimated annual incidence of 0.4–13.5 new cases per 100,000 population [1,2].The standardized incidence of rates of malignant neoplasm derived from major salivary glands and minor salivary glands was reported to be 1.04 per 100,000 in the Japanese population and was slightly less than that of 1.31 in the European Union [3].Despite their rarity, salivary gland neoplasms represent a wide variety of benign and malignant histological subtypes that is apparently unparalleled in comparison to any other organs
The aim of this study was to clarify the relative frequency, characteristics and time trends of various salivary gland tumors in a Japanese population by using large-scale multi-institutional data that were registered in the Hiroshima Tumor Tissue Registry (HTTR) over a period of 39 years in Hiroshima Prefecture, Japan
Patients were all of the cases diagnosed as having primary salivary gland tumors that were registered in the HTTR from 1973 to 2011, which was the most recent follow-up period when we started the present study
Summary
The standardized incidence of rates of malignant neoplasm derived from major salivary glands and minor salivary glands was reported to be 1.04 per 100,000 in the Japanese population and was slightly less than that of 1.31 in the European Union [3]. Despite their rarity, salivary gland neoplasms represent a wide variety of benign and malignant histological subtypes that is apparently unparalleled in comparison to any other organs. The best source from which to obtain information on the true relative frequency of tumors is the records of a large-scale multi-institutional registration data covering a wide area
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