Abstract
Specific binding of [ 3H]ryanodine to the rabbit cerebral microsomes was dependent on free Ca 2+ at micromolar concentrations and significantly increased by AMP-PNP and caffeine. Scatchard analysis showed a high and a low affinity binding site. The results suggest the presence of ryanodine binding sites which are activated by Ca 2+ but with low efficacy, and greatly modified by adenine nucleotide, Mg 2+ and also by caffeine.
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