Abstract
Background: Today there are several competing hypotheses trying to provide the explanation of mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The cholinergic hypothesis is derived from the theory of reduced synthesis of the neurotransmitter acetylcholine, while the amyloid hypothesis is based on material analysis of senile plaques or in brain tissue. There are some other theories such as virus, inflammation, and oxidative stress, etc. Apparently those hypotheses have not located the real root of Alzheimer’s disease.Conclusions: In this presentation, the author proposes a rationalized theory of human brain activity mechanism. The theory is derived from basic thermodynamic principles of Gibbs free energy and functional group interactions. By elucidating human memory system and the other brain activity mechanisms, we may come to a better understanding of the pathophysiology of MCI and AD. Since human memory is stored basically as free energy in protein conformation structures, avoidance of energy deficiency may be the key to the problem. By focusing development of products providing optimal energy supply at critical period of life, we may lead to a real alleviation or even reverse the courses of MCI and AD.
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