Abstract
The objective of the study was to compare the clinical characteristics and pregnancy outcomes of asymptomatic and symptomatic pregnant women with confirmed COVID-19 in the third trimester. Forty-one patients were enrolled in this study from two COVID-19 designated hospitals in Wuhan. Patients underwent chest CT scans for screening and were divided into two groups based on pneumonia-related syndromes. The clinical characteristics and pregnancy outcomes were reviewed and compared. Among the sample of pregnant women infected with SARS-CoV-2 in the third trimester, there was no mortality or severe complications in the mothers nor newborns. Nearly 40% of the patients in the study were asymptomatic. The most common pneumonia-related symptom in symptomatic pregnant patients was cough. Asymptomatic patients had a significantly shorter duration of hospitalisation and a lower rate of positive RT-PCR testing compared with symptomatic patients. There was no statistically significant difference in antibody test results between asymptomatic and symptomatic patients during hospitalisation, while the positive rate of IgM antibody testing was significantly lower in asymptomatic patients during follow-up. Clinical manifestation of pregnant women infected with SARS-CoV-2 were atypical and concealed. Screening of possible COVID-19 patients should be strengthened, through serial or combined testing of laboratory testing or radiological testing, before pregnant women are admitted to hospital.
Highlights
The objective of the study was to compare the clinical characteristics and pregnancy outcomes of asymptomatic and symptomatic pregnant women with confirmed COVID-19 in the third trimester
Several descriptive studies of the maternal and neonatal outcomes of pregnant women infected with SARSCoV-2 have been published [3], the pregnancy outcomes in asymptomatic mothers with COVID-19 are rarely reported and there is a lack of comparison of symptomatic and asymptomatic patients
The presence of SARSCoV-2 was determined in throat swab or nasopharynx swab specimens from the upper respiratory tract by real-time (RT)-PCR, according to the guidelines for COVID-19 issued by the Chinese Center for Disease Control and Prevention (CDC)
Summary
The objective of the study was to compare the clinical characteristics and pregnancy outcomes of asymptomatic and symptomatic pregnant women with confirmed COVID-19 in the third trimester. 19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in Wuhan, China, and has spread to most regions and countries around the world. Several descriptive studies of the maternal and neonatal outcomes of pregnant women infected with SARSCoV-2 have been published [3], the pregnancy outcomes in asymptomatic mothers with COVID-19 are rarely reported and there is a lack of comparison of symptomatic and asymptomatic patients. The aim of this study was to compare and evaluate the clinical characteristics and pregnancy outcomes of asymptomatic and symptomatic pregnant patients with COVID-19
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