Abstract
Acute kidney injury (AKI) is a common critical disorder in the elderly patients. Its incidence is increasing gradually. The presence of multiple comorbidities as well as age-related changes in the kidney, systemic vasculature and immunological system renders older patients more prone to AKI. Infection, hypovolemia, nephrotoxins, cardiovascular events, and surgery are common causes for ralated hospital-acquired AKI in the elderly. Patients with AKI are at increased risk for death and chronic kidney disease. The key to improve prognosis of AKI is early diagnosis and early intervention. At present, serum creatinine (Scr) combined with urine output remains the cornerstone for diagnosing and classifying AKI. However, urine output is also often susceptible to many factors such as use of diuretics and urinary tract obstruction; While the SCr level alone is a relatively late and imprecise biomarker for kidney dysfunction, which may lead to a delayed diagnosis. No proven treatment measures exist for AKI in elderly individuals except supportive therapy. A thorough understanding of the pathogenesis, etiology, clinical characteristics, complications, and prognosis of AKI in the elderly population is vital to preemptively reduce the incidence of AKI and hopefully create a better outcomes. Key words: Acute kidney injury; Aged; Prognosis; Risk factors; Prognosis; Treatment
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