Abstract
Background SARS-CoV-2 has spread worldwide with different dynamics in each region. We aimed to describe the clinical characteristics and to explore risk factors of death, critical care admission, and use of invasive mechanical ventilation in hospitalized patients with SARS-CoV-2 pneumonia in a high-altitude population living in Bogotá, Colombia. Methods We conducted a concurrent cohort study of adult patients with laboratory-confirmed SARS-CoV-2 pneumonia. Demographic, clinical, and treatment data were extracted from electronic records. Univariate and multivariable methods were performed to investigate the relationship between each variable and outcomes at 28 days of follow-up. Results 377 adults (56.8% male) were included in the study, of whom 85 (22.6%) died. Nonsurvivors were older on average than survivors (mean age, 56.7 years [SD 15.8] vs. 70.1 years [SD 13.9]; p ≤ 0.001) and more likely male (28 [32.9%] vs. 57 [67.1%]; p=0.029). Most patients had at least one underlying disease (333 [88.3%]), including arterial hypertension (149 [39.5%]), overweight (145 [38.5%]), obesity (114 [30.2%]), and diabetes mellitus (82 [21.8%]). Frequency of critical care admission (158 [41.9%]) and invasive mechanical ventilation (123 [32.6%]) was high. Age over 65 years (OR 9.26, 95% CI 3.29–26.01; p ≤ 0.001), ICU admission (OR 12.37, 95% CI 6.08–25.18; p ≤ 0.001), and arterial pH higher than 7.47 (OR 0.25, 95% CI 0.08–0.74; p=0.01) were independently associated with in-hospital mortality. Conclusions In this study of in-hospital patients with SARS-CoV-2 pneumonia living at high altitude, frequency of death was similar to what has been reported. ICU admission and use of invasive mechanical ventilation were high. Risk factors as older age, ICU admission, and arterial pH were associated with mortality.
Highlights
In December 2019, a cluster of cases of severe pneumonia of unknown cause were identified in Wuhan, China
We aimed to describe the demographic and clinical characteristics and to explore risk factors of death, intensive care unit (ICU) admission, and use of invasive mechanical ventilation in hospitalized patients diagnosed with SARS-CoV-2 pneumonia in Bogota, Colombia
Severity of pneumonia evaluated on admission was mild in 251 patients according to CURB-65 score (0 to 1, 73.3%), and 342 had low risk for in-hospital mortality according to a quick SOFA score (0 to 1, 96.3%)
Summary
In December 2019, a cluster of cases of severe pneumonia of unknown cause were identified in Wuhan, China. As of April 30th, 2021, more than 2.8 million cases and more than 70 thousand deaths of COVID-19 have been reported in Colombia [3] Factors such as male sex, increasing age, diabetes, cardiovascular diseases, chronic respiratory diseases, and obesity have been associated with increased risk of death by COVID-19 [4]. We aimed to describe the clinical characteristics and to explore risk factors of death, critical care admission, and use of invasive mechanical ventilation in hospitalized patients with SARS-CoV-2 pneumonia in a high-altitude population living in Bogota, Colombia. In this study of in-hospital patients with SARS-CoV-2 pneumonia living at high altitude, frequency of death was similar to what has been reported. Risk factors as older age, ICU admission, and arterial pH were associated with mortality
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.