Abstract
A 6-month-old girl presented with an abdominal mass and high serum levels of α-fetoprotein. Computed tomography showed an extremely large tumor of the liver, which was diagnosed with open biopsy as a well-differentiated hepatoblastoma. Left hepatic lobectomy was performed after regional chemotherapy, including cisplatin, which was effective. The biopsy specimen was transplanted to a nude mouse, and a xenograft was successfully established. The xenograft maintained the characteristics of the original tumor with regard to cell structure and the high serum level of α-fetoprotein in both hosts. A part of the xenograft was subjected to methylthiotetrazole assay. Cisplatin was most effective, as it had been clinically. Xenografts may be useful for determining the chemosensitivity of hepatoblastoma.
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