Abstract
：Objective To investigatethe effect of fast-aging on the excitability of hippocampus CA1 neurons in mouse and thepossible interaction between fast-aging and hippocampus. Methods Using brain slice andextracellular recording technique to record the firing of hippocampus CA1 neurons infast-aging(SA M-P/8) and normal control mice, after preprocessing, neural firing trainwere obtained. Using neural firing rate and inter-spike-inter to investigate interactionbetween fast-aging and hippocampal neural firing. Results The neural firing rate ofhippocampus CA1 neurons in fast-aging mice is (1.052±0.364) Hz(n=14), while the neuralfiring ratein normal control mice is (4.416±1.306) Hz(n=22). In fast-aging mice, 80.5%inter spike intervel(ISI) is longerthan 1sec, but in normal control mice, 95.6% ISI isshorter than 0.5sec. Conclusion The decreased firing rate of hippocampus CA1 and longerISI observed in the fast-aging mice indicates that fast-aging significantly inhibithippocampal CA1 neurons excitability. Key words: Fast aging; SAM-P/8 mouse; Hippocampus slice; CA1; Firing-rate
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