Characteristic of the urea-forming function of the liver of cats with chlamidiosis

Abstract

Currently, broad-spectrum antibiotics are widely used to treat bacterial infections. One of them is Azitronit containing 10% of azithromycin. The main objective of the work was to study the urea formation function of the liver of cats with chlamydia and the effect of the preparation Azitronit on it. All the animals studied were subjected to a clinical study according to the generally accepted method, in which special attention was paid to the condition of the organs that are most often affected by chlamydia - the eyes, mucous membranes of the external genital organs, and upper respiratory tract. Laboratory diagnosis was carried out by polymerase chain reaction. Determination of biochemical parameters on an IDEXX Catalist analyzer. It was found that in sick animals the content of total protein, urea, ammonia, glutamine and ornithine increases by 15.5%, 27.6%, 27.8%, 18.2% and 17.5%, respectively, compared with healthy ones. After treatment of animals, the studied indices decreased by 4.9% (total protein), 5.3% (urea), 18.3% (glutamine), 10% (ammonia) and 13.6% relative to the initial level (sick animals) (ornithine), but did not reach the animals of the control group and were higher by 11.1%, 23.5%, 11.7%, 10% and 4.5%, respectively. In the blood of cats with chlamydia patients, the content of a number of metabolites of the ornithine urea cycle increases, the activity of arginase and transamination enzymes increases, the content of total protein and ornithine, the concentration of ammonia, while increasing the concentration of urea, glutamine. After treatment with the drug Azitronit, the desired indices decrease, but do not reach the indices in healthy animals.