Abstract
Information about Parkinson’s disease (PD) patients with severe COVID-19 is scarce. We aimed to analyze the clinical characteristics, outcomes, and risk factors affecting the prognosis of PD patients with severe COVID-19 infection. Clinical data of severe COVID-19 patients admitted at the Union Hospital, Wuhan between 28th January and 29th February 2020 were collected and analyzed. 10 patients (1.96%) had a medical history of PD with a mean (SD) age of 72.10 (± 11.46) years. The clinical characteristics and outcomes of severe COVID-19 with and without PD patients were then compared. There was no significant difference in overall mortality between the PD and non-PD patients with severe COVID-19 (p > 0.05). In PD patients with severe COVID-19, the proportion of patients with critical type, disturbance of consciousness, incidence of complications, white blood cells count and neutrophils counts on admission seem higher in the non-survivors. PD patients with older age, longer PD duration, and late stage PD may be highly susceptible to critical COVID-19 infection and bad outcome. The PD patients with consciousness disorders and complications that progressed rapidly are at increased risk of death.
Highlights
Coronavirus disease 2019 (COVID-19) is an acute infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
It was showed that Parkinson’s Disease (PD) with older age and longer disease duration are susceptible to COVID-19 with a high mortality (Antonini et al 2020; Hainque et al 2020)
Patients with hypertension and diabetes had a median age of 68 years (IQR 61–74 years) and a mean (SD) age of 65.87 (± 11.86) years; while, those with cardiovascular disease and cerebrovascular disease had a median age of 67 years (IQR 62–76.5 years) and 81 years (IQR 64.25–83.75 years), respectively
Summary
Coronavirus disease 2019 (COVID-19) is an acute infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) It was first reported in Wuhan, China in December 2019 and quickly spread across the world within few months (Zhu et al 2020). This virus has poorer outcomes and higher mortality rates in older people and those with comorbidities or chronic diseases. This being the case, patients suffering from Parkinson’s Disease (PD) are likely to be susceptible to COVID-19 infection and evolve to a severe condition, and possible death, because of their old age and low immunity (Borges et al 2020; Helmich et al 2020; Shahid et al 2020). The risk factors for death and whether PD itself has a negative effect on COVID-19 patients have not been accurately defined
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