Abstract
The present study investigated the characteristics of diclofenac diethylammonium-containing NLC as function of ratio of glyceryl monostearate (GMS) and caprylic acid (mygliol 80) of 65:35; 75:25 and 85:15. There were three formulas and the composition of each formula were diclofenac diethylammonium 1.16%; glyceryl monostearate and caprylic acid with ratio (65:35; 75:25 and 85:15); Tween 80 5%; and phosphate buffer pH 6.0 ± 0.1 as dispersion medium. The result showed that each formula had different characteristic of particle size and efficiency entrapment. Particle size was analized by DelsaTMNano, F I (65:35) had particle size 134.467 ± 26.601 nm with PI 11.776; F II (75:25) had particle size 2252.233 ± 727.370 nm with PI 0.348; and F III (85:15) had particle size 1500.867 ± 219.673 nm with PI 0.260. The present Entrapment Efficiency (EE) carried out by centrifuge method and result of F I, F II and F III were 88.342 ± 0.52%, 73.764 ± 0.511% and 70.754 ± 0.665%, respectively. The result was analyzed by statistic with ANOVA one-way method with degree of confident 95% (a = 0.005). Research result revealed that the best characteristics of diclofenac diethylammonium in terms of particle size and % Entrapment Efficiency (EE) was F I with ratio of GMS and caprylic acid (mygliol 80) 65:35.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
