Abstract
Short-term cultures from 12 non-squamous cell carcinomas (NSCCs) of the head and neck were cytogenetically investigated. Three tumours were acinic cell carcinomas, two adenoid cystic carcinomas, three mucoepidermoid carcinomas, two carcinomas in pleomorphic adenoma, and two adenocarcinomas. Clonal chromosome aberrations were detected in all but one adenocarcinoma. Including our data, a total of 40 head and neck NSCCs with clonal aberrations have been described. Deletions of the long arm of chromosome 6 are the most common aberrations (11/40 cases); they have been detected in all types of NSCC except carcinoma in pleomorphic adenoma. Two aberrations seem to be closely associated with tumour type: t(6;9)(q21-24;p13-23), which has been seen in three of 11 adenoid cystic carcinomas (in two as the sole aberration), and structural rearrangements of 8q12-13, which have been detected in three of four carcinomas in pleomorphic adenoma.
Highlights
Sma_ Short-term cultures from 12 non-squamous ceD carcnomas (NSCCs) of the head and neck were cytoseneticaly investigted
Clonal chromosome aberrations were in al but one adenocarcinoma
Deletions of the arm of chromosome 6 are the most common aberrations (11/40 cases); they have b detected in all types of NSCC except
Summary
47,XX,+7 [22/47,XX,+ 18 [2/46,XX,del(4XqI2) [2/46,XX [21] 47,XX,+12 [2/48,XX,+7,+12 [21148,XXt(1;19Xq25,pl3),+8,+9 [2/46,XX [15] 45,X,-Y [51/47,XY,+Y [8V46,XY,t(1;6)q21;q21) [21/47,XY,t(12;16Xql5;q22),+16.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
