Abstract
We experienced 5 cases of clear cell adenocarcinoma (CCAC) of the cervix in the 10-year period from 2003 to 2012. Because a specimen from one of the cases was poorly preserved, we analyzed cytological features of the 4 remaining cases. Characteristic large, pale-staining atypical cells with prominent, round nuclei were seen in all cases. Additionally, a hobnail appearance and basement membrane-like substance were detected in 3 cases, and a mirror ball cluster-like morphology was found in 1 case. Cervical CCAC has been reported to be difficult to diagnose by cytology; however, we were able to diagnose these 4 cases by recognizing several characteristic cytological features.
Highlights
Clear cell adenocarcinoma (CCAC) of the cervix is a rare neoplasm that accounts for only 2-7% of cervical adenocarcinomas [1]
Reich et al reported that the clinicopathological findings and prognosis of surgically treated patients with stage IB-IIB clear cell carcinomas without exposure to DES were similar to those of patients with squamous cell carcinomas and non-clear cell adenocarcinomas [6]
In order to contribute to a better understanding and correct diagnosis of cervical CCAC, we evaluated the cytological features of 4 of these cases; 1 case was excluded due to poor preservation of the specimen
Summary
Clear cell adenocarcinoma (CCAC) of the cervix is a rare neoplasm that accounts for only 2-7% of cervical adenocarcinomas [1]. Many reports have described the occurrence of cervical and vaginal CCAC without history of exposure to DES [4]. A 70-year-old woman (gravida 2, para 2) did not participate in the routine cervical cancer screening and consulted a local clinic because of genital bleeding. Cytological findings indicated adenocarcinoma, and histological diagnosis by punch biopsy further indicated CCAC.
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