Abstract
α-Fetoprotein-producing gastric cancer (AFPGC) is a rare type of gastric cancer. The largest population of patients with AFPGC is found in China. In the present study, a total of 4,779 GC patients, including 317 AFPGC patients, from 11 clinical studies in China with a general AFPGC/GC ratio of 6.63% were summarized and analyzed. On the basis of analysis of the clinical data, the patients with AFPGC had larger tumor size, weaker cell differentiation, worse histopathological types, deeper serosal infiltration, more lymph node and liver metastases, poorer stages, shorter survival time and more positive expression of vascular endothelial growth factors than the patients without AFPGC. Our observation is consistent with previous results reported in studies of AFPGC. Overall, AFPGC is a subtype of GC with a poor prognosis.
Highlights
Abstract α-Fetoprotein-producing gastric cancer (AFPGC) is a rare type of gastric cancer
The general AFP is termed α-fetoprotein-producing gastric cancer (AFPGC)/GC ratio was 6.63%, which was consistent with the results from other countries and suggested the annual incidence of AFPGC was 2% to 3%
There was a total of 19 cases with VEGFpositive expression among these total 21 AFPGC cases (90.5%)
Summary
Xiao-Dong Li1,2, Chang-Ping Wu2*, Mei Ji2, Jun Wu2, Binfeng Lu3, Hong-Bing Shi and Jing-Ting Jiang1*. Information related to histopathological type was available in three studies (studies 1, 3 and 9) In these three studies, there was an aggregate a total of 112 AFPGC cases. Evaluation of clinical stage conditions Information related to serosal infiltration (T) was available in five studies (studies 3 through 6 and study 10) In these five studies, there was an aggregate total of 77 AFPGC cases. Information correlated with lymph node metastasis (N) was available in eight studies (studies 1 through 8) In these eight studies, there was an aggregate total of 203 AFPGC cases. Evaluation of pathological and histological conditions Information related to the tumor sites was available in three studies (studies 2, 5 and 6) These three studies comprised aggregate totals of 54 AFPGC cases and 483 non-AFPGC cases. 23 were AFPGC cases and 144 were non-AFPGC cases with observed tumors in the antrum
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