Abstract
Preparation of PVA-Collagen nanofiber plaster production begin by repairing the skin of catfish, then collagen is extracted with distilled water. Extracted collagen need to be frozen dry so that collagen can be obtained in the form of sheets, powder, or crystals. The next step is the production of PVA-Collagen nanofiber, a 10% solution of polyvinyl alcohol (PVA) is mixed with a previously prepared extracted collagen and stirred until it forms a homogeneous mixture. Next, PVA-Collagen nanofiber is formed by the electrospinning method. The results of characterization using FTIR found three main groups in six variations: amide group A; amide I; and amide II. Amide A has a wave number in the range 3300-3440 cm-1, amide I is in the range 1625-1690 cm-1, and amide II is in the range of 1480-1575 cm-1. Characterization was carried out to determine the surface morphology of the observation in the sample using Photomicrograph (200 µm) with magnification 10x, produced fiber diameter formed in variations of PVA-Collagen 1% 116-120 µm while in the variation of PVA-Collagen 1% + Chitosan 10 drops in diameter 41-50 µm.
Highlights
Skin sores and ulcers from heat, surgery, or diabetes are health problems in the world and have a heavy financial burden on the health care system 1
Photomicrograph was carried out to determine the distribution of polyvinyl alcohol (PVA)-Collagen and PVA-Collagen + Chitosan to determine the surface morphology
The fiber tested in this variation is 1% PVA-Collagen and 1% PVA-Collagen + 2% Chitosan, the selection of this varies based on the formed nanofiber has the desired thickness
Summary
Skin sores and ulcers from heat, surgery, or diabetes are health problems in the world and have a heavy financial burden on the health care system 1. The majority of wound care is made from natural polymers, such as alginate, collagen, chitosan, gelatin and hyaluronic acid 4. In this case, carboxymethyl chitosan (CMC) and collagen were selected for the preparation of wound dressing substrates because of their excellent biocompatibility, biodegradability and easy modification. CMC has a remarkable effect in inhibiting bacterial growth and supporting blood coagulation and collagen which can accelerate the process of wound healing 5
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