Abstract
Characterisation and Recognition by Immune Hosts of a Sheep Nematode Parasite Teladorsagia circumcincta Chitinase
Highlights
Teladorsagia circumcincta is a mucosal browser and resides in the abomasa of the ruminants
Recent industry-funded surveys in New Zealand found that 64% of sheep farms and 94% of beef farms have parasites that are resistant to at least one of the anthelmintics [1]
This study showed the close relationship between a T. circumcincta chitinase (TciCHT) to that from other helminth homologues
Summary
Teladorsagia circumcincta is a mucosal browser and resides in the abomasa of the ruminants. The parasite has a direct life-cycle where the eggs laid by the adult worms are passed on to the pasture through faeces and eggs develop into the infective stage larvae (L3), which are ingested and reside in the abomasa of the ruminants and develop into adult worms. Parasitic nematode worm infection is one of the biggest health problems for farmed ruminants worldwide. Parasitic worm infections are harmful to a host animal for many reasons and cause costly production losses and if left untreated, animals can die causing further economic loss to farmers. The control and productivity losses caused by parasitic nematodes cost the New Zealand livestock industry ~$700 million annually. Recent industry-funded surveys in New Zealand found that 64% of sheep farms and 94% of beef farms have parasites that are resistant to at least one of the anthelmintics [1]. It is really important to understand worm biology and look for the targets that are essential for the worm survival
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