Abstract
Objective: This study aims to demonstrate antifungal activity and in-vitroanalysis of fluconazole nanogel with different polymer concentration for seborrheic dermatitis. Methods: The class of antifungal drug- Fluconazole was used to formulate the nanogel with different concentrations of polymers. The prepared batches of nanogel were analyzed for its antifungal activity, ex-vivo skin permeation study, and skin thickness study. The animals are used in four groups for the in vivo antifungal activity of nanogel as control, disease, standard, and test. The prepared fluconazole (FLZ) nanogel was compared with marketed fluconazole gel. Results: The prepared formulation having hydroxymethyl cellulose (HPMC=1.5mg) as the polymer showed up with best properties among eight different batches. It was effective with a 38 mm inhibition zone in culture media of yeast Malassezia strain. The skin permeation study ensured 95% cumulative drug release in 18 hr. The ex-vivo studies also give the best result for F5 batch (HPMC=1.5mg) with a minimum skin thickness of 1.4 micrometer. Conclusion: In-vivo and ex-vivo studies on the different batches of fluconazole, when compared with marketed gel, showed evidence that nanogel of FLZ (1mg with HPMC=1.5mg) can treat seborrheic dermatitis.
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