Abstract
In Magnetic Resonance Tomography (MRT) image contrast can be improved by adding paramagnetic relaxation agents such as lanthanide ions. Here we report on the use of highly paramagnetic isostructural Fe(III)/4f coordination clusters with a [Fe10Ln10] core to enhance relaxation. Measurements were performed over the range of (1)H Larmor frequencies of 10 MHz to 1.4 GHz in order to determine the relevant parameters for longitudinal and transverse relaxivities. Variation of the lanthanide ion allows differentiation of relaxation contributions from electronic states and molecular dynamics. We find that the transverse relaxivities increase with field, whereas the longitudinal relaxivities depend on the nature of the lanthanide. In addition, the Gd(III) analogue was selected in particular to test the interaction with tissue observed using MRT. Studies on biofilms used in waste water treatment reveal that the behaviour of the high-spin clusters is different from what is observed for common relaxation agents with respect to the penetration into the biofilms. The Fe10Gd10 cluster adheres to the surface of the biofilm better than the commercial agent Gadovist.
Highlights
In Magnetic Resonance Tomography (MRT) and in NMR spectroscopy, paramagnetic molecules are of special importance regarding their relaxation behaviour in solution ( paramagnetic relaxation enhancement, PRE) and their influence on line shifts ( pseudocontact shift, PCS)
In Magnetic Resonance Tomography (MRT) and in NMR spectroscopy, paramagnetic molecules are of special importance regarding their relaxation behaviour in solution and their influence on line shifts
Herrling,e Susanne Lacknere and Harald Horne In Magnetic Resonance Tomography (MRT) image contrast can be improved by adding paramagnetic relaxation agents such as lanthanide ions
Summary
In MRT and in NMR spectroscopy, paramagnetic molecules are of special importance regarding their relaxation behaviour in solution ( paramagnetic relaxation enhancement, PRE) and their influence on line shifts ( pseudocontact shift, PCS). Several NMR systems were used in order to cover the interesting Larmor frequency range from 10 MHz to 1.4 GHz. The MRT images were obtained at 200 MHz applying different parameter schemes to obtain a dedicated contrast.
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