Abstract
The work was designed to investigate the levels of a novel serotonin-modulating anticonsolidation protein (SMAP), which activity directly depends on serotonin level, and biomarker cytochrome P-450 in the liver, gills and brain of Alburnoides bipunctatus eichwaldi caught in Khudat, Agstafachay, Kura and Araz rivers running over the territory of Azerbaijan. Noticeable downregulation of cytochrome P-450 and SMAP was observed in the liver and gills of fish caught in Agstafachay river relatively to the values obtained for the fish from unpolluted Khudat river. The levels of cytochrome P-450 and SMAP in liver of fish from Kura and Araz rivers exhibited significant opposite changes: downregulation of cytochrome P-450 level vs. upregulation of SMAP level. In the brain of fish from Agstafachay river the cytochrome P-450 was found to be somewhat downregulated, whereas in the brain of fish from Kura and Araz rivers SMAP was significantly upregulated. The results obtained are analyzed from the standpoint of adaptation and disadaptation processes of water organisms to the effects of pollutants.
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