Abstract
The level of virus-neutralizing antibodies (VNA) against rabies virus (RABV) glycoprotein (G) plays a crucial role in protection against rabies. Functional assays, such as the rapid fluorescent focus inhibition test (RFFIT) and the fluorescent antibody virus neutralization test (FAVN), are suitable for measuring the VNA levels in human and animal sera in the laboratory. However, these assays are time-consuming, expensive, and require live RABV, which means that they can only be performed in restricted reference laboratories. Based on the principle of immunochromatography and the VNA-binding activity of inactivated virus, we developed an immunochromatographic strip test called the “Rapid Neutralizing Antibody” (RAPINA) test for the qualitative or semi-quantitative determination of antibody levels. The theoretical basis of the RAPINA test is that the inactivated CVS-11 RABV binds with antibodies in the serum and is no longer detected by the immunochromatography strip, which detects G, so a band is not produced on the test strip.
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