Abstract
Matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry (MS) is a revolutionary identification method for microorganisms and has recently been introduced into clinical microbiology. At present, two identification systems, Microflex LT (Bruker Daltonics, Bremen, Germany) and VITEK MS (bioMérieux, Marcy l’Etoile, France), are commercially available, and both were approved for in vitro diagnostics by the Food and Drug Administration. The Bruker and bioMérieux MALDI-TOF MS systems differ in databases, algorithms used to identify organisms, and instrumentation. Numeric rankings are reported on different scales and are not directly comparable. Both MALDI-TOF MS systems allow a fast and accurate identification of most microbial strains and the differences are marginal.
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