Abstract
The structure of the neuromuscular form of the nAChR was the first studied and neuronal nAChRs share many common features with the muscle nAChRs. Each nAChR has five subunits and these subunits share common structural features such as the extracellular domain, four transmembrane regions, a channel that controls gating of cations and complex intracellular domains. The structures of each of these regions will be described in general. Neuronal nAChRs vary in subunit composition with these distinct subtypes possessing diverse function and pharmacology, but sharing the same basic structural features. This chapter will focus on the overall structure of the nAChR both from muscle and neurons. Some aspects of function are also presented here, but these are also spread throughout this book in reference to various roles of neuronal nAChRs.
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